美国Lumencor公司针对生物应用对光源的要求，发明了独有的专利技术—固态光源技术，该技术基于固态发光材料和最优化的控制器件，具有输出功率高，稳定性好，寿命长等优点，越来越被广泛应用于荧光显微镜，流式细胞仪、高通量筛选等荧光分析仪器。作为一种新型的光源，不需要配合热反射滤光片、准直透镜、光学调制器、快门等器件，一件光源满足了所有功能需求，可以直接替代目前常用的传统汞灯/氙灯光源及卤素光源等，是荧光显微镜最优的一个新选择。作为未来的主流光源，目前各大显微镜厂商，也已在官网上对Lumencor产品用于显微镜进行了详细的应用介绍。我们希望能够和您携手一并推动显微镜照明技术，提高显微成像的质量。 解决您目前的烦恼？您可以使用  
主要产品如下：
客户实例： 哈佛大学医学院的Nikon Imaging Center已成功将13台显微镜上的激发光源升级为固态光源。该中心的负责人Dr. Jenifer Waters告诉我们：相比这款光源在实验室维护费用的降低作用，其更大的优点是提高了实验研究数据的质量。  |
Fluorescence microscopy requires an intense light source at the specific wavelengths that excite fluorescent dyes and proteins. Traditionally a white light is employed, a Metal Halide, Mercury or Xenon arc lamp. Although such broad spectrum lamps can generate ample light at desired wavelengths, only a small percentage of the projected light is useful in any particular application. The other wavelengths need to be suppressed to avoid background noise that reduces image contrast and obscures the fluorescent light emissions. Light engines enhance S/N, eliminate stray UV and IR radiation, synchronize with camera exposure time and simply generate more useable light than their arc lamp predecessors.
Optogenetics is the combination of genetic and optical methods to control specific events in targeted cells of living tissue in the millisecond timescale. The electrical and biochemical events may be monitored via introduction of fast light-activated channels and enzymes that allow temporal characterization yet maintain cell-type resolution through the use of specific targeting mechanisms. Optogenetics studies in freely moving animals may now be conducted with a cost-competitive light engine as a replacement to a family of lasers. Lumencor light engines provide the temporal precision needed to keep pace with functioning, intact, living biological systems; the ease of use of a pre-aligned multicolor output; and the safety and price advantages of a non-laser based illuminator.
Lumencor’s red/green/blue (RGB) light engine has superior power over any lamp based illuminator used in surgical procedures. Moreover, the light engine incorporates powerful NIR sources to strategically excite fluors designed for specific and selective identification of a particular pathology during surgical procedures. The NIR outputs as well as other wavelengths can be used for targeted fluorophore excitation. The light engine may be tuned to match any color temperature. A fourth output may be included, cyan. This is particularly important for minimally invasive surgery where the RGCB components can be balanced to offset red in the surgical field. The LE can provide high blue and green content, to match the camera chip and yield a field of view that images in high contrast. One can then superimpose the fluorophore excitation, giving the surgeon a superior image quality within which to operate.
Lumencor light engines provide for clinical chemistry and immunochemical analyses with powerful, stable, narrow band, light across the UV-VIS-NIR spectrum. Our light engine illumination subsystems are designed to replace existing excitation subsystems in today’s instrument architectures with a long-lived light sources as well as all the optical components to deliver well characterized, robust and reproducible light for your analysis needs. Lumencor light engines embody stable source material, well characterized optics, robust electronics and enough power to provide you a light source that will uniformly flood-illuminate even high density samples in parallel.
Digital Pathology is an image-based information environment enabled by computer technology that allows for the management of information generated from a digital slide. Digital pathology is enabled in part by virtual microscopy, which is the practice of converting glass slides into digital slides that can be viewed, managed, and analyzed. Lumencor’s light engine offers state of the art illumination for this high performance, digital microscopy application: power in discrete UV-Vis-NIR bands, spectral & power stability, microsecond switching, no external filters or shutters, standard and custom imaging colors, minimal heat generation, computer control TTL/RS232 and boasts a lifetime greater than 20,000 hours. No other lighting system in the biotech market offers this entire ensemble of features.
Assays performed in whole cells or intact tissue sections allow for monitoring a more complete set of biological parameters to a particular compound or drug target, and are thus considered “high-content” analyses. High-content analysis can be applied to all stages of the drug discovery process and is well suited to tracking the intracellular processing, localization, and movement of fluorescently labeled molecules such as proteins. It is possible to simultaneously monitor multiple targets, such as components of a signaling pathway of interest. In addition, monitoring the activity of membrane proteins and a cell’s electrophysiological response can provide information that standard high-throughput biochemical analysis simply cannot tackle. Single cells can be monitored, providing greater subtlety in the evaluation of the variability of the response to a particular drug or treatment. Light engines help here just as they do in microscopy with powerful, stable, robust, spectral pure light.
Whether your method requires illumination of a plurality of capillaries, beads, spots or wells, Lumencor designs suitable light engines that provide stable, pure excitation at less than half the cost of your current light subsystem. A Lumencor light engine can be designed to fit into your existing light subsystem footprint. Address each sample in highly parallel analyses with the exact same excitation light to give improved reproducibility and robustness to high-density formats. Lumencor’s long-lived sources mean little instrument down time, fewer costly re-validations and lower overhead.
Scientists can analyze variations in gene sequence and gene expression to identify the defective genes and polymorphisms that are associated with a specific disease. About half of such research is conducted in the field of cancer. These techniques provide initial insight into whether a potential drug merits further research and as such are immensely useful to drug discovery and development. The plurality of samples on a typical microarray is simply too demanding for most light sources. As a consequence scanners move chips or delivery optics to built up an image over time. Lumencor can eliminate that problem. By providing enough light to uniformly irradiate even the highest density chips, the noise and cost associated with moving parts and “scanning” are minimized and even eliminated. Lumencor light engines are being used today to obtain quiet, cost effective images based on single or multiple wavelengths.
